A magnetic solid phase extraction technique followed by liquid chromatography with a\nfluorescence detector for naproxen analysis in human urine samples was developed. The method\nincludes the extraction of naproxen with a magnetic solid synthetized with magnetite and poly\n4-vinylpriridine, followed by the magnetic separation of the solid phase and desorption of the analyte\nwith methanol. Under optimal conditions, the linear range of the calibration curve was 0.05â??0.60 microg\nL-1, with a limit of detection of 0.02 microg L-1. In all cases values of repeatability were lower than\n5.0% with recoveries of 99.4 1.3%. Precision and accuracy values are adequate for naproxen (Npx)\nanalysis in urine samples.
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